Alopecia Areata, Hair Loss, Causes, Treatment

Alopecia describes lack of hair from regions wherein hair commonly grows. It is available in a number of styles with a number of reasons. The maximum not unusualplace shape is male sample baldness, or androgenetic alopecia.


In all varieties of received baldness, pores and skin that has formerly been covered can be subjected to robust sunlight. Hats need to be worn to save you burning and probable later malignant change.


Normal hair cycle[1]

Each follicle produces some of hairs at some point of a lifetime. There are 3 phases:


Anagen or increase section at the scalp lasts among 3 and 5 years and the hair grows at about 1 cm a month. The period of the anagen section varies from man or woman to man or woman and it determines how lengthy hair will develop if now no longer cut. Usually approximately 85% is in anagen section.

Catagen section follows the anagen section and is an involutional level that lasts round  weeks.

Telogen, or dormant, section lasts approximately 3 months. The hair stays withinside the follicle however does now no longer develop.

At the give up of the telogen section the follicle begins offevolved manufacturing of recent anagen hair which displaces the antique one from the follicle, with the antique one being shed. In a few animals that is synchronised to provide moults however in human beings it's far unsynchronised and round 50 to one hundred hairs drop out every day, basically unnoticed. Sometimes human beings undergo a duration of greater predominantly telogen section and that they lose a variety of hair in brushes and combs, inflicting a great deal tension; however, baldness does now no longer develop.



There are some of kinds and styles of alopecia. Aetiology, epidemiology and control will range among them. Some of the greater not unusualplace varieties of alopecia (in addition mentioned below) are:


Male sample baldness, or androgenetic alopecia (male).

Female sample baldness, or androgenetic alopecia (girl).

Alopecia areata.

Telogen effluvium (TE).

Anagen effluvium.


Alopecia associated with or due to pores and skin situations or systemic infection, together with:

Seborrhoeic dermatitis.

Lichen planus and discoid lupus erythematosus.

Tinea capitis.


Secondary syphilis.

Thyroid disorder.

Iron deficiency.

Determining the purpose will manual control and diagnosis.


Androgenetic alopecia - male sample[2]

This is a function sample of balding in guys, which turns into greater not unusualplace with age. There can be bitemporal recession and/or a critical recession to provide a function horseshoe form of closing hair.



Genetic predisposition thru some of extraordinary genes.

A wide variety of mechanisms play a part. Hair follicles emerge as smaller over time. Terminal hairs are regularly changed via way of means of thinner hairs with much less pigmentation. Hairs are withinside the anagen section for much less time and less hairs are on this developing section. The give up end result is shorter hairs which do now no longer attain the pores and skin surface. Telogen hairs are greater loosely connected and fall out greater without problems. Finally, there may be accelerated time among telogen section losing and anagen section regrowth.

Believed to be androgen-dependent; however, androgen degrees in affected guys are typically normal. The situation is an issue of give up-organ sensitivity to androgens and guys who're poor on their head might also additionally have an abundance of hair over the relaxation in their bodies. Dermal cells convert testosterone into dihydrotestosterone. For motives that aren't clear, affected hair follicles emerge as greater touchy to dihydrotestosterone, which then reasons the hair follicles to shrink.


Increasingly not unusualplace with age.

Initial symptoms and symptoms visible in teenage years.

Half of fellows are tormented by the age of 50.

Rate of development and severity of give up end result are extraordinarily variable.

Significant ethnic variations - white guys are affected 4 instances greater than the ones of Afro-Caribbean origin. Alopecia has a tendency to arise later and greater slowly in Asian guys.

Management[3, 4]

Doing not anything is possibly to be the fine remedy alternative. For many guys, there may be no powerful low cost remedy; therefore, reputation is the control strategy. Counselling or assist companies can be useful.


Aesthetic remedy alternatives encompass wigs and hairpieces and surgical transplantation. The latter is highly-priced and now no longer to be had at the NHS, despite the fact that more moderen strategies bring about advanced consequences.


There are  pharmacological alternatives authorised for this situation. Neither is to be had at the NHS. There is a excessive price of discontinuation of remedy because of loss of pride with the consequences.


Minoxidil. Topical software of minoxidil two times every day, in both 2% or 5% shape can be used. It is to be had over the counter or via way of means of personal prescription. The more potent formula can be greater powerful; it can, however, purpose greater irritation. Minoxidil is much more likely to be powerful withinside the early levels of balding than as soon as it's far installed. It need to be used for as a minimum six months to set up efficacy after which used indefinitely if you want to hold any effect.

Finasteride. Oral finasteride in a dose of one mg every day can be powerful. It is simplest to be had via way of means of personal prescription. A trial of as a minimum six months is wanted and, if powerful, remedy wishes to be persevered indefinitely. There is a small threat of damaging sexual side-effects. There is proof of mild efficacy.

Other alternatives that have been used encompass dutasteride and low-degree laser mild remedy[5, 6]. Evidence isn't always but enough for these, or for different miscellaneous alternatives, as mainstream remedies[7].


Androgenetic alopecia - girl sample[8]

This is a function sample of hair loss in genetically predisposed ladies. There is a greater diffuse hair loss than in guys, mainly affecting the pinnacle of the scalp.



Terminal hairs are regularly changed via way of means of smaller hairs with much less pigmentation. Fewer hairs are withinside the anagen section. Telogen hairs are greater loosely connected and fall out greater without problems.

The genetic foundation and the position of androgens are much less properly installed than in male sample hair loss.

There can be awesome early-onset and late-onset bureaucracy.


Reported occurrence charges range widely.

It will increase after the menopause.

It influences round one 1/3 of white Caucasian ladies over the age of 70.

There is ethnic variant with it being much less not unusualplace in ladies of Oriental origin.

Rate of development is variable however ladies hardly ever move absolutely bald.


Address fears of baldness.

Reassurance - general baldness is unlikely.

Note that phrases consisting of "hair thinning" are greater applicable than "balding".

Encourage beauty upgrades thru hair styling, colouring and products.

Support companies or counselling can be of benefit.

Doing not anything is possibly to be the fine remedy alternative.

Aesthetic alternatives encompass hair pieces, wigs and surgical transplantation. Surgery is highly-priced and now no longer to be had at the NHS.

Topical 2% minoxidil is the simplest certified pharmaceutical agent. It must be carried out two times-every day indefinitely. Response is understated and there can be side-effects (consisting of undesirable facial hair increase).

Finasteride need to now no longer be utilized in ladies.

Evidence isn't always enough to apply anti-androgenic sellers consisting of spironolactone, drospirenone and cyproterone[7].

Alopecia areata[9, 10]

Alopecia areata is a continual inflammatory disorder, which influences hair follicles and once in a while nails. The ordinary medical presentation is with properly-circumscribed bald patches at the scalp or beard area. There isn't anyt any scarring or scaling at the pores and skin. Exclamation mark hairs (brief damaged hairs tapering toward the proximal give up) can be determined across the margins and are stated to be pathognomonic however now no longer invariable. The greater intense varieties of alopecia areata are:


Alopecia totalis - general lack of scalp hair.

Alopecia universalis - general lack of all frame hair.


This situation is of unknown aetiology, despite the fact that there may be a great deal assist for an autoimmune component. It is greater not unusualplace in received thyroid disorder, vitiligo, diabetes and collagen diseases. Stress is once in a while given as a element however it can be that the disorder is the purpose in preference to the end result of pressure. There is a bent for it to run in families (in particular the greater intense cases) and it's far connected to a number of genes and gene complexes. Around 20% have a fine own circle of relatives history.


Epidemiology and herbal disorder course

Estimated occurrence withinside the UK is 15 in keeping with 10,000 of the population.

It can have an effect on any age however onset is maximum not unusualplace in youth and adolescence. Incidence peaks among the a while of 15 and 29. 50-60velop a primary bald patch earlier than the age of 21.

Males and girls are affected equally.

There is nail involvement in 10-15%.

Spontaneous remission takes place in as much as 80%, despite the fact that recurrence is the norm.

14-25% development to alopecia totalis or alopecia universalis.

Severity at presentation is the fine indicator of lengthy-time period outcome.

As properly as intense disorder, elements related to a poorer diagnosis encompass nail abnormalities, onset at a younger age, widespread alopecia, involvement of the scalp margin, atopy and related autoimmune disorder.

Alopecia areata at the beard area. It can arise off the scalp however is much less obvious.





Extent: over 50% hair loss is taken into consideration widespread and need to set off expert referral.

Investigate in addition if there may be idea of different autoimmune disorder.

Assess mental distress.

Explanation and schooling are important. Stress excessive degrees of spontaneous remission while thinking about remedy in milder cases.


No remedy alternative need to be mentioned and is suitable if:


There is proof of hair regrowth.

Treatment isn't always wanted.

There is much less than 50% hair loss (until the man or woman affected desires for remedy).

Primary care remedy alternatives


For non-pregnant adults simplest.

Not to be used at the face.

Trial of effective topical steroid - eg, betamethasone valerate 0.1%, fluocinolone acetonide 0.025% or hydrocortisone butyrate 0.1%.

Off-licence use of a totally effective topical steroid - eg, clobetasol propionate 0.05% scalp software.

Warn of excessive failure price of remedy and additionally that it can take as a minimum 3 months to take effect.

Warn that if hair increase takes place, it to start with can be great and depigmented. It may be dyed with a non-peroxide-primarily based totally dye even as anticipating go back to its normal colour.

Consider counselling and mental assist.

Specialist remedy alternatives

Although some of remedies were proven to bring about hair regrowth, none adjust the lengthy-time period outcome. Response charges are typically bad. Options dermatologists might also additionally don't forget encompass:


Intralesional corticosteroids.

Topical corticosteroids.

Topical immunotherapy.

Topical minoxidil.

Topical dithranol

Topical or systemic psoralen plus ultraviolet A (PUVA) mild remedy.

Oral ciclosporin.

Dermatography (tattooing). Particularly powerful for eyebrow loss.

Wigs. (Certain wigs may be prescribed at the NHS via way of means of a expert. Human hair wigs are higher however greater highly-priced and simplest to be had at the NHS if there may be a contra-indication to acrylic hair.)

Telogen effluvium[11, 12]

Telogen effluvium (TE) takes place while physiological or hormonal pressure triggers many hairs to transport into telogen section. When new hairs seem in anagen section they push out the telogen hairs and that is among one and 6 months, on common 3 months, after the preliminary insult. People with TE word they're losing greater hair than normal and frequently gift with handfuls of hair determined at the pillow, on a broom or withinside the plughole.


This may be an acute or continual situation however the continual situation may fit unnoticed. The acute situation can be caused via way of means of a number of elements:


Childbirth. TE is expected to have an effect on one 1/3 to 1 1/2 of of ladies following childbirth. It is likewise referred to as telogen gravidarum.

Crash dieting, anorexia nervosa or low protein intake.

Sudden weight reduction or nutritional restrict following bariatric surgical operation.

Iron deficiency.

Acute febrile infection or intense infection.

Major surgical operation and intense trauma.

Heavy metallic poisoning, together with selenium, arsenic and thallium.

Medication changes - eg, contraceptives, antidepressants.

Chronic diffuse telogen hair loss can be idiopathic (affecting ladies simplest) or can be secondary to an natural purpose. Possible reasons encompass:


Thyroid disorder.

Iron-deficiency anaemia.

Chronic infection consisting of malignancy, mainly lymphoproliferative malignancy and any continual debilitating infection, consisting of systemic lupus erythematosus, give up-level continual kidney disorder or liver failure.

Zinc deficiency.

Chronic starvation, malabsorption or hypoproteinaemia.

Medication, together with beta-blockers, anticoagulants, retinoids, lithium, carbamazepine and immunisations.

Management is the correction of any topics that require attention (consisting of bad diet) and reassurance that hair will go back in a rely of months. Minoxidil is from time to time prescribed for this situation.


Anagen effluvium[13]

Anagen effluvium takes place while hair manufacturing is arrested withinside the anagen section. This specially occurs while most cancers chemotherapy, immunosuppression or radiotherapy reasons fast hair loss. Doxorubicin and cyclophosphamide are in particular infamous however maximum antimitotics may have this effect.


Rarely, anagen effluvium may be a characteristic of pemphigus vulgaris, or be due to trauma, stress or publicity to chemical compounds consisting of thallium, boron and arsenic.


Within some months of preventing chemotherapy the hair will typically go back. It may be very psychologically negative for human beings in a inclined situation. Scarves, hairpieces and wigs can be useful. Patients present process most cancers chemotherapy are entitled to unfastened NHS wigs. If the remedy consists of hormonal manipulation which can set off warm flushes, a wig can be very uncomfortable to wear. Minoxidil shortens the alopecia via way of means of approximately 50 days. Local cooling of the scalp will also be beneficial.


Trichotillomania[14, 15]

Trichotillomania, or hair-pulling disease, is a behavioural disease which might also additionally have hyperlinks with obsessive-compulsive disease. It can be related to different situations, mainly temper and tension disorders. It can arise at any age, however begins offevolved most usually in adolescence. Hair loss is asymmetrical and has an uncommon form, with damaged hairs throughout the bald patch which aren't without problems removed. Single or a couple of regions may be affected, together with eyebrows, eyelashes and pubic hair. There is minimum or no inflammation.


Genetic and environmental elements were implicated. It can be feasible to peer that the character wraps the hair round a finger and pulls on it, possibly while focusing on some thing consisting of while studying. Most people file pleasant emotions at some point of or after pulling out hairs. There can be boredom, anxiety or tension earlier than pulling episodes and a good sized discount in such bad feelings following pulling. Management includes behavioural modification.


This is classed as a psychiatric disease however consequences in a shape of disturbing alopecia. Traction alopecia also can arise with hairstyles that pull tightly at the hair and it can cause frontal recession.


Trichobezoar (swallowing hair which bureaucracy a ball withinside the intestines) may be a complication.


Psychotherapy (especially habit-reversal remedy) and cognitive behavioural remedy are typically first-line remedies with a few proof base. Unlicensed medicines from time to time determined to be beneficial and that have been studied encompass:


Antidepressants of all classes.

Antipsychotics, mainly olanzapine.




A Cochrane assessment determined mild proof for efficacy of clomipramine, olanzapine and N-acetylcysteine however warned that consequences need to be interpreted with warning because of the small wide variety of research and small length of these research.


Other reasons of alopecia

There are some of different situations which could cause lack of hair. These encompass:


Scalp situations:

Infection - impetigo, boils, abscesses, tinea capitis (in particular animal ringworm).


Seborrhoeic dermatitis - produces massive quantities of dandruff and is frequently related to thinning of hair.

Atopic dermatitis.


Traction alopecia may be due to tight hairstyles and hair grooming gadgets consisting of curling irons and straighteners.

Scarring alopecia. Conditions inflicting alopecia which might be related to scarring of the pores and skin are acknowledged together as cicatricial alopecia. These are uncommon and encompass:

Certain infections consisting of folliculitis, boils or tinea capitis.


Discoid lupus erythematosus.

Lichen planopilaris.

Secondary syphilis:

Causes an average sample of hair loss referred to as glades withinside the wood.

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Hair Transplantation by Turkey Hair Expert

Turkey Hair Expert provides high quality and safe hair transplant in Turkey at its contracted premier clinic, using the most advanced techniques and technologies. With a patient-centric and ethical approach, Turkey Hair Expert offers high-quality hair transplantation in Turkey with its experienced doctors and medical team.

For 3 years we have been chosen as the best hair transplant clinic in Istanbul (2016-2017-2018). Since our foundation we have dedicated all our knowledge and skills to hair transplantation, becoming true leaders in the sector.

As Turkey Hair Expert we are proud to offer competence and professionalism to patients from all over the world, who choose the experience of Dr.Emine Karabash, Dr.Mustafa Yilmaz and the highly qualified team of professionals.

Our Team

A team of professionals dedicated to your well-being. Hair transplantation is an art: it requires solid knowledge, undeniable technical expertise and an artistic eye. But your stay doesn't end with your hair transplant session. The administrative team welcomes you and remains at your disposal throughout the day to make sure you have a good time, in complete confidence and relaxation.The team in operation has an experience of at least 5 years and maximum 15 years.

Mustafa Yilmaz

My vision of hair transplantation is totally in line with this perspective: to be at the service of regained well-being through effective techniques that give natural results. The hair, in women of course, but in men, it is the force of life, it is the finery. Losing them is truly an injury, a trauma. It’s terrible!

Also, I enjoy listening to my patients and never judging them. I am then able to give them the best advice and allow them to regain their self-confidence.

I naturally surrounded myself with a caring, expert and extremely rigorous team in its field to be sure to offer men and women who suffer from baldness solutions that work, without ever ignoring safety and reliability.

The used techniques depend on Dr. Mustafa Yilmaz decision after doing the medical diagnosis, Choi Pen / DHI - Sapphire - Micro FUE are used normally in our operations.

Emine Karabash

I started dermatology almost 15 years ago now and thanks to my encounters with other dermatologists, I quickly turned to medical aesthetics.

More and more women and men want to feel good about their hair, and when this is the case, one gains confidence in oneself, in everyday life, in social life and in work.

I have also always remained "classic", in this movement that is now called the "Soft touch", namely to privilege discretion, elegance, and of course, naturalness. Not ostentatious! I prefer to repair what is damaged, rather than change or modify.

The used techniques depend on Dr Emine’s decision after doing the medical diagnosis, Choi Pen / DHI - Sapphire - Micro FUE are used normally in our operations.

Ayshe Yalchin

She is the one who sees you in consultation and who makes the diagnosis. On D-Day, Ayse. starts the procedure with local anesthesia in your donor area. She is present throughout your intervention, ensuring its perfect completion, with the support of her team of experts.


At first I had some nerves surrounding the procedure, however, these were soon gone when reassured by the professional staff. So much so I came back for a second hair transplant. The procedure was painless and was completed on the same day, allowing for visible results with minimal scarring.


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Before & After

Hair Transplantation & Methods

DHI Hair Transplant

The DHI hair transplantation method, which is called direct hair implant, is performed by implanting the follicles using a special tool with fine-tipped needles.

DHI Hair Transplant

The DHI hair transplantation method, which is called direct hair implant, is performed by implanting the follicles using a special tool with fine-tipped needles.

While performing this process, there is no incision or stitch scar at all. The purpose of this transplantation method is to minimize the time that the hair follicles stay outside and place the follicles with a good density and continuously.

Fue Hair Transplant

With the FUE method (Follicular Unit Extraction), the hair follicles are taken one by one with a special micro-motor and the aid of local anesthesia.

FUE Hair Transplant

With the FUE method (Follicular Unit Extraction), the hair follicles are taken one by one with a special micro-motor and the aid of local anesthesia; grafts are repositioned afterwards in the bald areas, according to the angle and the natural direction of hair growth.

Generally the donor area (the area from which the follicles are taken) is the back of the head. Since the nape follicles are genetically stronger and more resistant to shedding, this region is preferred as a donor area. However, if the area is not dense enough, grafts are collected from other parts of the body.

Sapphire Fue Hair Transplant

Although the Sapphire Fue hair transplantation method is not much different from other transplantation methods.

Sapphire Fue Hair Transplant

Although the Sapphire Fue hair transplantation method is not much different from other transplantation methods, with this technique the micro channels are opened by fine tips of sapphire, a precious stone.

On the contrary, in classical fue, the process is performed by metal slit. Likewise, after the follicles are taken one by one from the donor area, they are carefully placed according to the direction and angle of the hair.

Beard and Mustache

Beard and mustache transplantation is a procedure designed for those with a loss of beard or mustache.

Beard and mustache transplantation

Beard and mustache transplantation is a procedure designed for those with a loss of beard or mustache. Beard and mustache are an important part of a man’s appearance, as much as their hair.

This method is recommended in cases of hair loss caused by the testosterone hormone, for those with thinning beard hair wishing to have a bushy beard. It is possible to get a healthy and natural look of the beard by undergoing a beard transplant operation.

FUE Titanium Technique

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Sapphire FUE Technique

   Sapphire FUE Technique

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  Local Anesthesia for painless operation process

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DHI Technique

   DHI Technique

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   Blood Tests

  Washing and Control

  Medications box after the operation

  Plasma injection

  Checking the grafts using a Microscope device

  Local Anesthesia for painless operation process

  Laser Therapy

  Ice grafts feeding device

  Treatment and vitamin box

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